Diabetes-related Mortality in Adults with Cystic Fibrosis. Role of Genotype and Sex
نویسندگان
چکیده
منابع مشابه
Cystic fibrosis related diabetes.
Diabetes is a frequent complication seen in cystic fibrosis patients as they reach adulthood. Cystic fibrosis related diabetes (CFRD) is distinguished as a separate entity with features that include progressive loss of islet beta cell mass and insulin deficiency, as well as insulin resistance. Abnormalities in glucose tolerance may be detectable for many years prior to the development of overt ...
متن کاملCystic Fibrosis Related Diabetes
Diabetes mellitus and glucose intolerance are common in adolescent and adult patients with CF (Lanng et al, 1995; Moran et al, 1998). The prevalence of CF related diabetes (CFRD) increases with age (Moran et al, 1998) and in patients over 20 years of age may be as high as 53% (Lanng et al, 1995). CFRD occurs in up to 30% of individuals by the age of 25 and is invariably associated with pancreat...
متن کاملCystic Fibrosis-Related Diabetes
Cystic fibrosis (CF) is the most common autosomal recessive disorder in Caucasian populations. Individuals with CF have seen significant increases in life expectancy in the last 60 years. As a result, previously rare complications are now coming to light. The most common of these is cystic fibrosis-related diabetes (CFRD), which affects 40-50% of CF adults. CFRD significantly impacts the pulmon...
متن کاملCystic Fibrosis-Related Diabetes: Screening and Diagnosis
CFRD — Cystic fibrosis-related diabetes — is the most prevalent extrapulmonary complication of cystic fibrosis and is associated with decline in pulmonary function, poor nutritional status, and greater mortality. Although our general understanding of CFRD has increased, difficult areas remain in its pathophysiology, screening, diagnosis, and management that require further research and developm...
متن کاملCystic fibrosis-related diabetes in childhood.
Since the early 1990s the management of children with cystic fibrosis (CF) has come a long way and advances in both nutritional and medical care have resulted in a median age of survival of 30-35 years, as compared with a life expectancy of <1 year in the 1950s. The first definitive reports of glucose intolerance or diabetes in CF are from 1955. The combination of CF and related diabetes (CFRD)...
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ژورنال
عنوان ژورنال: American Journal of Respiratory and Critical Care Medicine
سال: 2015
ISSN: 1073-449X,1535-4970
DOI: 10.1164/rccm.201403-0576oc